The fifth precept is to not use up alcohol or more widely eveything intoxicant. For instance, you can take medecines, but only to cure a medical problem otherwise it is dangerous. As well as destructing health, alcohol or an other drug (any) can compel you to commit evil deeds and being unaware of it, some of these can be irreparable.
What is more important than having a clear mind and a healthy body ? Even cigarettes are a poison you should avoid because it only brings disadvantadges including for the people around.
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